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      research Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

      140 citations, February 2014 in “Neuron”
      The study revealed that the opioid system, particularly through delta opioid receptors (DOR), played a significant role in regulating cutaneous mechanosensation, including both touch and pain. DORs were found on myelinated mechanoreceptors associated with structures like Meissner corpuscles and Merkel cell-neurite complexes. These receptors also appeared on a subset of nociceptors coexpressing mu and delta opioid receptors. Activation of DORs at the central terminals of these mechanoreceptors inhibited synaptic input to the spinal dorsal horn by blocking voltage-gated calcium channels. This mechanism suggested that targeting DOR could be a potential strategy for managing injury-induced mechanical hypersensitivity.
      The Dynamics of the Skin’s Immune System

      research The Dynamics of the Skin’s Immune System

      306 citations, April 2019 in “International Journal of Molecular Sciences”
      The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

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