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This study found that repeated finasteride administration in male Wistar rats led to increased depression-like behavior, suggesting an animal model for investigating finasteride's neuropsychiatric effects is viable.

In this study, male Wistar rats with obesity showed reduced depressive-like behaviors, brain inflammation, and oxidative stress after long-term finasteride treatment, suggesting potential benefits of finasteride in obese conditions, while lean rats experienced adverse effects including metabolic disturbances and depressive-like behaviors.

In this study, chronic finasteride administration in male rats led to depression- and anxiety-like behaviors only in specific tests and moderately affected hippocampal synaptic plasticity, possibly due to adaptive plasma corticosterone level changes over time.

In this rodent study, researchers found that the drug finasteride may reduce anxiety and depression-like behaviors in a model of aging, despite inducing metabolic disturbances and depressive-like behaviors in young rats, suggesting potential considerations for its use in elderly populations.

This study found that finasteride treatment in male rats has lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation, and gut microbiota composition even one month after discontinuation.