46 citations
,
October 2012 in “Seminars in reproductive medicine”
This review describes how recent discoveries in genetic defects and alternative pathways in androgen biosynthesis are reshaping our understanding of male sexual differentiation, but it presents no new clinical findings.
45 citations
,
April 2018 in “Nature Reviews Urology”
This review discusses the molecular mechanisms of masculinization involving androgen signaling and their roles in male embryonic development and conditions like hypospadias and prostate cancer, and reports no clinical results.
This study demonstrated that high oral doses of finasteride caused external genital abnormalities in male rhesus monkey fetuses, but intravenous doses did not lead to abnormalities.
This study found that prenatal exposure to finasteride in rats disrupted male reproductive development, causing physical alterations such as delayed preputial separation and increased nipple retention.
A 24-year-old male using dutasteride for hair loss is worried about its effects on fertility and future children's health. Users advise consulting a doctor, possibly switching to finasteride, or stopping dutasteride before conception due to its impact on sperm count.
A user shared their successful experience with hair regrowth and transitioning from male to female using minoxidil, finasteride, Nutrafol, microneedling, and hormone replacement therapy (HRT). They expressed gratitude for the results and encouraged others to explore treatments that align with their personal goals.
Finasteride may pose a risk during pregnancy, so using a condom is recommended if a partner is pregnant. It is advised to stop finasteride before trying to conceive due to potential effects on fetal development.
A user expressed concern about using low-dose topical finasteride while conceiving, but was reassured that the risk of affecting a fetus is negligible. The user stopped using finasteride during pregnancy and switched to minoxidil and ketoconazole, while others shared experiences and advice on using these treatments safely.
A user shared their hair loss journey, starting treatments with topical minoxidil and finasteride at 17, and later adding oral versions and dutasteride by age 20, but still experiencing hair loss. Others suggested that the treatments have likely slowed the progression, and some recommended considering a hair transplant or adjusting medication, while expressing concerns about the potential side effects of starting such treatments at a young age.