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    Glossary Macules

    flat, discolored skin spots under 1 centimeter wide

    Macules are flat, distinct, discolored areas of skin that are usually less than 1 centimeter in diameter. They can be red, brown, or white and are not raised or depressed compared to the surrounding skin. For example, freckles and flat moles are types of macules. In a clinical context, macules can be indicative of various conditions, including infections, allergic reactions, or other dermatological issues.

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      Adam10 Haploinsufficiency Causes Freckle-Like Macules in Hairless Mice

      research Adam10 haploinsufficiency causes freckle-like macules in Hairless mice

      13 citations , July 2012 in “Pigment Cell & Melanoma Research”
      In this study, researchers identified a new dominant mutation in Hairless mice, called Pied, resulting from a deletion in the Adam10 gene, which causes freckle-like skin pigmentation by inhibiting melanocyte expansion.
      Skin Features in Myotonic Dystrophy Type 1: An Observational Study

      research Skin features in myotonic dystrophy type 1: An observational study

      8 citations , March 2015 in “Neuromuscular Disorders”
      This study found that adult patients with Myotonic Dystrophy type 1 exhibited a higher prevalence of various morphofunctional, inflammatory, and proliferative skin disorders compared to healthy controls.
      Description of Skin Lesions

      research Description of skin lesions

      December 2016
      This chapter provides an overview of terminology for various skin lesions, including primary and secondary types, but does not report new findings or results.