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research Expression of μ-Opiate Receptor in Human Epidermis and Keratinocytes

111 citations , August 1998 in “Journal of Investigative Dermatology”

This study found that human epidermal keratinocytes express a functional μ-opiate receptor at both the mRNA and protein levels, potentially playing a role in skin physiology and pathology.

research Role of neurosteroid allopregnanolone on age-related differences in exercise-induced hypoalgesia in rats

4 citations , November 2018 in “Journal of pharmacological sciences”

This study found that low-intensity exercise improved pain relief in aged rats through increased brain allopregnanolone levels, while high-intensity exercise was effective in both adult and aged rats via a different mechanism.

research The Opioid Receptor Influences Circadian Rhythms in Human Keratinocytes through the β-Arrestin Pathway

January 2024 in “Cells”

This study found that activation of delta-opioid receptors in keratinocytes may delay the expression of the PER2 gene, suggesting a possible link to cancer development through circadian rhythm disruption.

research Eph Receptors and Ephrins: Therapeutic Opportunities

222 citations , October 2014 in “Annual Review of Pharmacology and Toxicology”

This review discusses the roles of Eph receptors and ephrins in various diseases, highlighting their potential as therapeutic targets, but it presents no new research findings.

research The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches

83 citations , January 2004 in “Pharmacology & Therapeutics”

This review explores the potential role of pregnane neurosteroids in modulating alcohol withdrawal symptoms, suggesting a therapeutic target for treating alcohol dependence, but reports no new clinical results.

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community Quitting kratom stopped my hairloss by 80%

in Research/Science 67 upvotes 2 years ago

Quitting kratom reduced hair loss by 80% for a 23-year-old male. Others discussed kratom's effects and potential side effects on hair health.

community Trying to understand finasteride side effects and post finasteride syndrome

70 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community Oral Minoxidil and Grapefruit Juice

in Research/Science 96 upvotes 3 years ago

The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

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