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research Effects of vinblastine and its metabolites on nausea and alopecia associated receptors

December 2018

This study found that vinblastine's metabolites show binding affinities for receptors linked to nausea and alopecia, suggesting potential changes to its structure could minimize these side effects during chemotherapy.

research The potential role of acetylcholine receptors in acne inversa (HS) pathogenesis

1 citations , June 2006 in “Experimental dermatology”

In this study, researchers identified similar presence of various nicotinic and muscarinic AChRs in lesional and normal epidermis, suggesting that tobacco-delivered nicotine may exacerbate acne inversa by interacting with endogenously produced acetylcholine.

research DcR3 reprograms macrophage plasticity to promote wound healing and hair regeneration

January 2026 in “Journal of Dermatological Science”

This study suggests that DcR3 can reprogram macrophages towards a reparative state, enhancing wound healing and hair follicle regeneration, making it a potential target for treating chronic wounds and alopecia.

research The local hypothalamic–pituitary–adrenal axis in cultured human dermal papilla cells

9 citations , June 2020 in “BMC Molecular and Cell Biology”

This study found that stress hormones, particularly CRF, can inhibit hair growth and induce hair loss by affecting human dermal papilla cells and hair follicles, suggesting a functional HPA axis in these cells.

research 409 ANDROGEN RECEPTOR GENE POLYMORPHISM (SNP RS6152) – ITS RELATIONSHIP TO ANDROGEN-SENSITIVE GENES EXPRESSION IN BENIGN PROSTATIC HYPERPLASIA, CARCINOMA OF THE PROSTATE AND ANDROGENETIC ALOPECIA

March 2011 in “European Urology Supplements”

Gene variation affects prostate issues and hair loss.

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community Dutasteride vs Finasteride and Steroid

in Progress Pictures 87 upvotes 11 months ago

Dutasteride is preferred over finasteride for hair loss due to fewer side effects. Combining dutasteride with minoxidil and RU58841 is effective for hair regrowth, even during steroid use.

community Oral Minoxidil Secret Very important

in Minoxidil 237 upvotes 1 year ago

Oral minoxidil can cause side effects like shortness of breath and constipation, which may be reduced by taking it in the morning. Some users experience no side effects, while others switch to topical treatments or adjust their dosage and timing to manage symptoms.

community Been on Dut for 2 1/2 years. AMA

in Finasteride/Dutasteride 20 upvotes 9 months ago

The user shares a positive experience with Dutasteride for hair loss, noting increased hair density and minimal side effects after switching from Finasteride. They prefer oral Dutasteride and avoid Minoxidil due to its inconvenience and potential risks.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Hair loss over a year following depression and taking antidepressants

in Side effects? 200 upvotes 8 months ago

A 33-year-old experienced significant hair loss after a depressive episode and taking paroxetine, possibly due to telogen effluvium or androgenic alopecia. Suggestions included reducing alcohol, considering finasteride and minoxidil, and consulting a doctor about antidepressant side effects.

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