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    GlossaryLymphopenia

    abnormally low level of lymphocytes in the blood

    Lymphopenia, also known as lymphocytopenia, is a condition characterized by an abnormally low level of lymphocytes in the blood. Lymphocytes are a type of white blood cell crucial for the immune system, and their deficiency can make the body more susceptible to infections. This condition can result from various factors, including autoimmune diseases, certain infections, malnutrition, or the side effects of medications.

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      Idiopathic CD4+ T-Lymphocytopenia

      research Idiopathic CD4+ T-Lymphocytopenia

      27 citations, September 1992 in “The Lancet”
      ICL is a condition with low CD4+ T cells like AIDS but not caused by HIV, and normal CD4+ T cell counts may vary between men and women.

      research Case Report: Extensive Digital Gangrene as a Primary Manifestation of Late-Onset Systemic Lupus Erythematosus

      1 citations, September 2022 in “F1000Research”
      A 56-year-old man with no prior history of conditions typically associated with digital gangrene presented with systemic lupus erythematosus (SLE) and digital gangrene as one of the initial symptoms. He exhibited joint pain, hair loss, photosensitivity, mouth ulcers, malar rash, dyspnea, and digital pain. Laboratory tests showed lymphocytopenia and elevated C-reactive protein, with positive antinuclear antibodies. Despite initial treatment with hydroxychloroquine, methylprednisolone, cyclophosphamide, and calcium blockers, the lesions did not improve. However, after two infusions of rituximab, there was a significant improvement in vasculitis lesions and partial improvement in dyspnea. This case highlights digital gangrene as a rare primary manifestation of late-onset SLE.

      research Case Report: Extensive Digital Gangrene as a Primary Manifestation of Late-Onset Systemic Lupus Erythematosus

      August 2022 in “F1000Research”
      A 56-year-old man with no prior risk factors presented with systemic lupus erythematosus (SLE) and digital gangrene as initial symptoms. He exhibited joint pain, hair loss, photosensitivity, mouth ulcers, malar rash, dyspnea, and digital pain. Laboratory tests showed lymphocytopenia and elevated C-reactive protein, with positive antinuclear antibodies. Pulmonary tests indicated fibrosis and restrictive disease. Despite initial treatment with hydroxychloroquine, methylprednisolone, cyclophosphamide, and calcium blockers, the lesions persisted. Rituximab infusions led to significant improvement in vasculitis lesions and partial relief of dyspnea. This case highlights digital gangrene as a rare primary manifestation of late-onset SLE.
      Clinical Manifestations of Toxic Shock Syndrome

      research Clinical Manifestations of Toxic Shock Syndrome

      176 citations, August 1981 in “JAMA”
      Toxic Shock Syndrome mainly affects menstruating women, can recur, and is linked to staph bacteria, with rapid treatment being crucial.
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