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research Protein loss quantification of abraded virgin and abraded bleached hair according to Bradford assay

11 citations , March 2005 in “International Journal of Cosmetic Science”

This study found that the Bradford assay is a sensitive and reproducible alternative to the Lowry test for quantifying hair protein loss during brushing, with bleached hair releasing more protein than virgin hair.

research Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle

11 citations , October 2017 in “Journal of Investigative Dermatology”

This study found that topical application of mitochondrial electron transport chain inhibitors stimulated hair follicle stem cell activation and hair regrowth in aged mice by promoting lactate production.

research Modulating testosterone pathway: a new strategy to tackle male skin aging?

6 citations , September 2012 in “Clinical Interventions in Aging”

This study found that honokiol inhibits enzymes related to testosterone degradation in vitro, suggesting its potential as a lead compound for developing antiaging bioactive ingredients for men.

research Characteristics of flutamide action on prostatic and testicular functions in the rat

30 citations , June 1988 in “Journal of Steroid Biochemistry”

This study found that combining Flutamide and an LHRH agonist in adult male rats effectively inhibited prostatic growth and reduced androgen-sensitive prostatic activity markers to levels similar to castrated rats.

Inhibitory Activities of Some Traditional Chinese Herbs Against Testosterone 5α-Reductase and Effects of Cacumen Platycladi on Hair Regrowth in Testosterone-Treated Mice

research Inhibitory activities of some traditional Chinese herbs against testosterone 5α-reductase and effects of Cacumen platycladi on hair re-growth in testosterone-treated mice

25 citations , November 2015 in “Journal of Ethnopharmacology”

This study found that Cacumen platycladi extract significantly promoted hair growth and reduced dihydrotestosterone levels by inhibiting 5α-reductase activity in an androgen-sensitive mouse model.

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community Promising reply to PP405 inquiry from Bill Lowry, one of its lead scientists

51 upvotes 1 year ago

PP405 is a potential hair loss treatment that may reactivate dormant hair follicles, with Phase 3 trials expected. Some users are cautious, suggesting using finasteride in the meantime, while others are skeptical about PP405's effectiveness.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community New York Magazine article - the Great Unbalding

48 upvotes 1 year ago

PP405, a potential treatment for male pattern baldness, shows promise with some participants experiencing hair regrowth in early trials. However, it is not yet considered a cure and may be used alongside existing treatments like minoxidil and finasteride.

community PP405 will be available on Everychem soon apparently

97 upvotes 1 year ago

PP405 is a potential hair loss treatment, but its safety and effectiveness are uncertain. Users advise caution and suggest waiting for more data before purchasing unverified versions.

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Experts

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Hair Loss Specialist
Dr. Scott Lowry, MD
Tinley Park, IL, United States

Clinics

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Dr. Scott Lowry, MD