22 citations
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September 2008 in “Brain & development” In this study on rats, valproic acid was associated with reduced biotinidase enzyme activity and higher alopecia rates, but biotin supplementation did not significantly affect alopecia occurrence.
In this study, a copper-deficient diet in rats led to a significant decrease in blood and liver copper levels without causing clinical symptoms, while hair leachable copper and bone copper remained unchanged.
January 2020 in “Journal of Clinical Biochemistry and Nutrition” This study observed that lower serum zinc levels in patients with chronic liver disease were linked to a higher prevalence of symptoms like dermatitis, taste disorder, and alopecia, suggesting these symptoms may be associated with zinc deficiency.
15 citations
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May 2006 in “Brain & development” The authors concluded that administering biotin may help prevent alopecia caused by reduced biotinidase activity during valproic acid therapy in rats.
April 2026 in “NSUWorks (Nova Southeastern University)” This review concludes that creatine monohydrate is a safe and effective supplement, offering potential health benefits beyond athletic performance; however, it addresses concerns regarding its use among specific populations and effects on various health aspects.