157 citations
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June 2015 in “Psychoneuroendocrinology”
This study observed that hair cortisol and cortisone concentrations were higher in older individuals and those with diabetes mellitus, highlighting their potential significance for assessing somatic health.
This study found that cortisol levels, a biomarker of chronic stress, significantly increased in the post-COVID-19 lockdown period compared to pre-lockdown and during-lockdown periods, especially among females and young adults, reflecting sustained psychological stress from the pandemic.
June 2026 in “Comprehensive Psychoneuroendocrinology”
In this study, researchers observed a curvilinear relationship between loneliness and hair cortisol concentration among older adults at elevated cardiovascular risk, with cortisol levels higher at low-to-moderate loneliness and lower at higher loneliness, though results were sensitive to some data exclusions.
This study established age-adjusted reference intervals for hair cortisol in children from birth to 18 years, finding higher cortisol levels in infants possibly linked to slower hair growth.
a synthetic cortisol used for anti-inflammatory effects
Can hydrocortisone be used together with other treatments like minoxidil or steroid injections?Clinicians do use a mild steroid cream to settle the scalp irritation minoxidil can cause, but no verified trial tests hydrocortisone added to minoxidil or to corticosteroid injections, and prolonged scalp use risks skin thinning — combining it is a decision to take with a prescriber.
What are the risks of long-term hydrocortisone use on the scalp?Dermatology reviews describe long-term topical corticosteroid use as causing skin thinning, delayed healing, greater infection risk, possible suppression of the body's own cortisol, and rebound flares on stopping — and over-the-counter hydrocortisone labels limit use to about a week without a doctor's direction.
How do you safely apply hydrocortisone cream or lotion to the scalp without overusing it?The over-the-counter hydrocortisone label sets the limits: a thin film on the affected patch, no more than three or four times a day, and no longer than seven days without a doctor's direction — and the scalp absorbs corticosteroids more than most skin, so prolonged use raises the risk of thinning skin.
Can a liquid formula with Procapil do more than your usual multivitamin?Procapil is a cosmetic ingredient, not an approved hair-loss drug: the published studies on it are small and test it in combination with caffeine or platelet-rich plasma, so none isolates its own effect, and the percentages quoted in marketing come from the ingredient supplier's unpublished studies. Vitamins are reported to help hair only where there is a deficiency, so the two are aimed at different problems rather than ranked against each other.
The user experienced significant hair regrowth over 8 months using finasteride, minoxidil, and a custom topical mix including progesterone, cortisone, and alpha 5 estradiol. They reported no side effects and noticed improvement around the third month.
The user discusses their experience with minoxidil for hair loss, noting that drinking coffee may reduce its effectiveness. They observed better results with the liquid solution and no coffee compared to using the foam solution and drinking coffee.
Minoxidil alone is not effective for significant hair regrowth; combining it with finasteride or dutasteride is necessary. Additional treatments like hair transplants, microneedling, or oral medications are recommended for better results.
A user developed a rash after 3 years of using Kirkland minoxidil foam, possibly due to a change in ingredients. They are considering switching to Foligain or Rogaine foam to avoid further issues.
A 22-year-old male is using a combination of oral Minoxidil, Finasteride, topical solutions, and supplements to combat male pattern baldness, with plans to add RU58841. Some users suggest adding treatments targeting androgen receptors and question the necessity of certain supplements.