18 citations
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August 2012 in “Clinical and Experimental Dermatology” This study concluded that a 3% IGF-1 liposomal gel improved hair thickness and growth in hamsters without inducing significant hepatotoxicity or myelotoxicity, suggesting its potential as a safe hair-loss treatment.
29 citations
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August 2017 in “Skin appendage disorders” This study found that IGF-1 likely plays a crucial role in regulating hair growth and alopecia, with balding scalp follicles secreting less IGF-1 than nonbalding counterparts.
27 citations
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February 2014 in “Experimental Dermatology” This study found that dermal papilla cells from balding scalp follicles secrete significantly less insulin-like growth factor-1 and its binding proteins, suggesting a mechanism contributing to male pattern baldness.
September 2025 in “Current Issues in Molecular Biology” This study highlights IGF-1's role in promoting hair follicle proliferation, vascularization, and growth, suggesting its potential as a treatment target for hair loss disorders like androgenetic alopecia, though more research on delivery methods and long-term effects is needed.
January 2020 in “Menoufia Medical Journal” This study found that the expression of IGF-1 receptor was significantly reduced in women with female androgenetic alopecia compared to healthy controls.