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research Immunohistochemical dissection of cystic panfolliculoma focusing on the expression of multiple hair follicle lineage markers with an insight into the pathogenesis

7 citations , June 2017 in “Journal of Cutaneous Pathology”

This study reports a case of cystic panfolliculoma, highlighting the role of epithelial-mesenchymal interactions in its pathogenesis and explaining its histological resemblance to trichofolliculoma.

Nestin as a Marker of Unipotent Embryonic and Adult Progenitors Differentiating into an Epithelial Cell Lineage of the Hair Follicles

research Nestin is a marker of unipotent embryonic and adult progenitors differentiating into an epithelial cell lineage of the hair follicles

1 citations , October 2022 in “Scientific reports”

This study found that nestin-expressing progenitor cells, capable of becoming ORS keratinocytes, are present in both developing and adult mouse hair follicles.

research Stem cell identification-in vivo lineage analysis versus in vitro isolation and clonal expansion

17 citations , March 2012 in “The Journal of Pathology”

This article argues that lineage labeling with genetic markers is the gold standard for identifying epithelial stem cells, contrary to the view that in vitro methods alone are sufficient.

research Six SNPs and a TTG indel in sheep desmoglein 4 gene are in complete linkage disequilibrium

2 citations , July 2011 in “AFRICAN JOURNAL OF BIOTECHNOLOGY”

This study identified genetic variations in the DSG4 gene among sheep, revealing valuable markers for assessing their impact on wool traits.

research Lineage Identity and Location within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin

159 citations , September 2018 in “Journal of Investigative Dermatology”

This study identified two cell surface markers, FAP and CD90, that distinguish between papillary and reticular fibroblasts in human skin, suggesting distinct functions and distribution in dermal layers.

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Community Join

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community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

7 upvotes 5 months ago

AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

140 upvotes 11 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community My Theory Of Androgenic Alopecia

16 upvotes 9 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Loosing your hair (young) feels like loosing your identity. Ain’t it right?

in Satire 4 years ago

The emotional and psychological impact of hair loss in young people, how to cope with it, and potential treatments such as finasteride, RU58841, Minoxidil, SMP, and hair transplants.

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Learn

1 / 801 results

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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