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GlossaryGonadotropin-Releasing Hormone Agonists (LHRH agonists)

medications that initially boost, then suppress, sex hormone production

Gonadotropin-Releasing Hormone Agonists (GnRH agonists) are medications that mimic the natural hormone GnRH, which regulates the release of other hormones like luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. Initially, they increase the production of these hormones, but with continuous use, they suppress their release, leading to reduced levels of sex hormones such as testosterone and estrogen. This makes them useful in treating hormone-sensitive conditions like prostate cancer, endometriosis, and certain types of breast cancer.

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research Hormonal Manipulation of Benign Prostatic Hyperplasia

18 citations, November 2012 in “Current opinion in urology”

Finasteride and dutasteride are equally effective and safe for treating benign prostatic hyperplasia.

research Therapeutic Control of Androgen Action

7 citations, January 1994 in “Annual Reports in Medicinal Chemistry”

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

research Recent Discoveries and Developments of Androgen Receptor-Based Therapy for Prostate Cancer

17 citations, January 2015 in “MedChemComm”

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

research Cardiovascular Effects of Hormone Therapy for Prostate Cancer

18 citations, July 2015 in “Drug Healthcare and Patient Safety”

Hormone therapy for prostate cancer can increase heart risks, especially in men with heart conditions.

research Annotated Patent Selections

January 2000 in “Expert Opinion on Therapeutic Patents”

The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.

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community Why haven’t we seen anything about this

in Research/Science 18 upvotes 4 years ago

A double blind, placebo-controlled study that looked into the potential effectiveness of topical fluridil for treating male androgenetic alopecia, showing increased anagen to telogen ratios with no reported side effects on libido or sexual performance.