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GlossaryGonadotropin-Releasing Hormone Agonists (GnRH analogues)

medications that initially boost, then suppress, sex hormone production

Gonadotropin-Releasing Hormone Agonists (GnRH agonists) are medications that mimic the natural hormone GnRH, which regulates the release of other hormones like luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. Initially, they increase the production of these hormones, but with continuous use, they suppress their release, leading to reduced levels of sex hormones such as testosterone and estrogen. This makes them useful in treating hormone-sensitive conditions like prostate cancer, endometriosis, and certain types of breast cancer.

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research Cyproterone Acetate in the Treatment of Sexual Disorders: Pharmacological Basis and Clinical Experience

30 citations, July 2009 in “Experimental and clinical endocrinology & diabetes”

Cyproterone acetate effectively treats sexual disorders by reducing sexual functions and is generally well-tolerated.

research An Unusual but Important Cause of Hyperandrogenism in Women

November 2018 in “Endocrine Abstracts”

A woman's high testosterone levels were caused by a rare ovarian tumor, not the initially diagnosed condition.

research Tamoxifen for Flutamide/Finasteride-Induced Gynecomastia

49 citations, December 1997 in “Urology”

Tamoxifen effectively treats gynecomastia without causing impotence.

research Redefining Hormone Resistance in Prostate Cancer

38 citations, December 2009 in “Therapeutic Advances in Medical Oncology”

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

research Key Targets of Hormonal Treatment of Prostate Cancer: The Androgen Receptor and 5α-Reductase

29 citations, July 2009 in “BJU international”

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

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community Why haven’t we seen anything about this

in Research/Science 19 upvotes 4 years ago

A double blind, placebo-controlled study that looked into the potential effectiveness of topical fluridil for treating male androgenetic alopecia, showing increased anagen to telogen ratios with no reported side effects on libido or sexual performance.