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GlossaryGonadotropin-Releasing Hormone Agonists (LHRH agonists)

medications that initially boost, then suppress, sex hormone production

Gonadotropin-Releasing Hormone Agonists (GnRH agonists) are medications that mimic the natural hormone GnRH, which regulates the release of other hormones like luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. Initially, they increase the production of these hormones, but with continuous use, they suppress their release, leading to reduced levels of sex hormones such as testosterone and estrogen. This makes them useful in treating hormone-sensitive conditions like prostate cancer, endometriosis, and certain types of breast cancer.

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research The Effect of Treatment with an LH-RH Agonist (Buserelin) on Gonadal Activity, Growth, and Bone Maturation in Children with Central Precocious Puberty

34 citations , May 1987 in “European Journal of Pediatrics”

Buserelin safely and effectively suppresses early puberty, potentially improving final height.

research Recent Discoveries and Developments of Androgen Receptor-Based Therapy for Prostate Cancer

17 citations , January 2015 in “MedChemComm”

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

research Clinical Applications of Antiandrogens

29 citations , October 1988 in “Journal of Steroid Biochemistry”

Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.

Sequential Estrogen-Progestin Addition to Gonadotropin-Releasing Hormone Agonist Suppression for the Chronic Treatment of Ovarian Hyperandrogenism: A Pilot Study

research Sequential Estrogen-Progestin Addition to Gonadotropin-Releasing Hormone Agonist Suppression for the Chronic Treatment of Ovarian Hyperandrogenism: A Pilot Study

2 citations , December 1994 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

The treatment effectively reduced hair growth and was safe for patients with PCOS, but it needs better bleeding control.

research The Dihydrotestosterone Hypothesis of Prostate Cancer and Its Therapeutic Implications

57 citations , January 1986 in “The Prostate”

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

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community Why haven’t we seen anything about this

in Research/Science 17 upvotes 5 years ago

A double blind, placebo-controlled study that looked into the potential effectiveness of topical fluridil for treating male androgenetic alopecia, showing increased anagen to telogen ratios with no reported side effects on libido or sexual performance.

community Bloodwork after 8 months on finasteride, is this normal?

in Update 28 upvotes 1 year ago

A user on finasteride for 8 months shared bloodwork results showing increased testosterone and estradiol levels, with concerns about high LH. Responses advised monitoring for symptoms but noted levels are within reference ranges.

community How’s my pre fin lab work. Age 40

in Chat 6 upvotes 1 year ago

A user shared their pre-finasteride lab results, including DHT, estradiol, testosterone, SHBG, prolactin, FSH, and LH levels. Another user responded, cautioning against making unsupported claims about side effects and recovery.

community Which labs / blood baseline markers to check before beginning treatment?

in Finasteride/Dutasteride 6 upvotes 4 years ago

The conversation is about which blood tests are essential to check before starting hair loss treatment with finasteride or dutasteride. The tests mentioned include DHT, PSA, Estrogen/Estradiol, Testosterone, FSH, and LH.

community Bloodwork before fin/dut impact on progesterone level

in Finasteride/Dutasteride 10 upvotes 1 year ago

A 26-year-old man who had a hair transplant and used minoxidil with good results is now experiencing shedding and considering finasteride. He's concerned about high progesterone and mild erectile dysfunction before starting the treatment.

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