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This case study suggests that low leptin levels in obese hyperandrogenic postmenopausal women might indicate the presence of androgen-secreting tumors.

In this study, isotretinoin treatment for acne vulgaris significantly increased serum adiponectin and leptin levels but had no significant effect on BMI or ghrelin levels.

In this study, HIIT increased adiponectin levels and improved cholesterol profiles in women with PCOS, but did not change leptin or vaspin levels.

This study suggests that specific mutations in the MFN2 gene, including the p.Arg707Trp allele, can result in tissue-selective mitochondrial dysfunction leading to excessive upper body fat growth and low leptin levels.

This study reports that patients with specific MFN2 mutations, including p.Arg707Trp, exhibit significant upper body fat overgrowth with suppressed leptin production, suggesting tissue-selective mitochondrial dysfunction and potential therapeutic targets.