research Hair cycle control by leptin as a new anagen inducer
This study found that leptin acts as an inducer of the anagen phase in hair follicles, suggesting its role as a potential player in hair biology.
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5 / 1000+ results research Regulation of the Wound Healing Response during Aging
This review examines the complexities of age-related skin healing and discusses how translating findings from model organisms to humans could enhance understanding and treatment of impaired regeneration in aging populations, but it reports no new clinical results.
research Author response: Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression
This study reports that patients with specific MFN2 mutations, including p.Arg707Trp, exhibit significant upper body fat overgrowth with suppressed leptin production, suggesting tissue-selective mitochondrial dysfunction and potential therapeutic targets.
research Decision letter: Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression
This study suggests that specific mutations in the MFN2 gene, including the p.Arg707Trp allele, can result in tissue-selective mitochondrial dysfunction leading to excessive upper body fat growth and low leptin levels.
research Telogen elongation in the hair cycle of ob/ob mice
In this study, ob/ob mice were found to have a prolonged telogen hair cycle phase from 10 to 24 weeks, suggesting their potential as a model for studying telogen effluvium.
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