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GlossarySkin Permeation (Skin Absorption)

process where substances pass through skin into bloodstream

Skin permeation, also known as transdermal absorption or percutaneous absorption, refers to the process by which substances pass through the skin and enter the bloodstream. This process involves the movement of molecules through the outermost layer of the skin (the stratum corneum), into the deeper layers, and eventually into the circulatory system. It is a critical concept in dermatology and pharmacology, particularly for the development of topical medications and transdermal drug delivery systems.