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This article provides an overview of diagnosing Cushing's syndrome, emphasizing the importance of assessing clinical signs and the appropriate use of first-line biochemical screening.

In this study, a 37-year-old female with resistant hypertension and signs of Cushing's syndrome and primary aldosteronism was found to have normal cortisol levels but high levels of cortisol and aldosterone via adrenal venous sampling, leading to a diagnosis confirmed by right adrenalectomy.

Proximal hair cortisol is a reliable tool for diagnosing Cushing's Syndrome.

This case report describes a challenging diagnosis of Cushing’s syndrome using endocrine tests and imaging, which ultimately identified an adrenal etiology. Successful treatment involved a non-invasive desmopressin stimulation test and right adrenalectomy, leading to improvement in symptoms and health outcomes for the patient.

These guidelines recommend testing thyroid function in patients with obesity due to common hypothyroidism, and highlight that weight loss is crucial for addressing hormonal imbalances, with only modest weight loss benefits from treating endocrine disorders.