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February 2022 in “Journal of the American Academy of Dermatology” This review discusses biotin supplementation for dermatological conditions and highlights the lack of strong evidence supporting its efficacy, as well as the potential for laboratory testing interference.
This review highlights the potential analytic interference of high-dose biotin with immunochemical tests, which may lead to diagnostic errors and suggests pausing biotin consumption before laboratory testing.
This source highlights concerns about the safety and efficacy of dietary supplements marketed for hair loss, citing a lack of FDA testing and potential risks such as adverse side effects, interference with medical tests, and withholding of ingredient information.
April 2019 in “Journal of the Endocrine Society” The researchers reported a case of falsely elevated testosterone in a teen, due to immunoassay interference, demonstrating that liquid chromatography tandem-mass spectrometry provides more accurate testosterone measurement, emphasizing the need for thorough analysis when clinical results are inconsistent.
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December 2023 in “Diagnostics” This review discussed the variability in measuring serum testosterone levels and emphasized the need for standardizing testing and sharing updated treatment protocols to manage male hypogonadism effectively. It also highlighted the importance of considering secondary hypogonadism causes and suggested consulting with endocrinologists for optimal management.