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GlossaryKLF4 (Kruppel-like factor 4)

transcription factor regulating cell growth and differentiation

KLF4, or Kruppel-like factor 4, is a protein that plays a crucial role in regulating cell growth, differentiation, and maintaining stem cell pluripotency. It is involved in various biological processes, including skin and hair follicle development, and has been studied for its potential implications in cancer and regenerative medicine.

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Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound Healing

research Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound Healing

23 citations , June 2012 in “PLOS ONE”

KLF4 is important for maintaining skin stem cells and helps heal wounds.

Extracellular Vesicles From 3D Cultured Dermal Papilla Cells Improve Wound Healing Via Krüppel-Like Factor 4/Vascular Endothelial Growth Factor A-Driven Angiogenesis

research Extracellular Vesicles From 3D Cultured Dermal Papilla Cells Improve Wound Healing Via Krüppel-Like Factor 4/Vascular Endothelial Growth Factor A-Driven Angiogenesis

1 citations , January 2023 in “Burns and trauma”

Tiny particles from 3D-grown skin cells speed up wound healing by promoting blood vessel growth.

Advanced Medical Treatments for Hair Loss

research Advanced Medical Treatments for Hair Loss

October 2025 in “Cell Transplantation”

New hair loss treatments like stem cells and gene therapy show promise but need more research for safety and effectiveness.

The Role of ATP-Dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity

research The Role of ATP-Dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity

January 2018 in “Stem cell biology and regenerative medicine”

ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.

Wnt Signaling: The Good and the Bad

research Wnt Signaling: The Good and the Bad

48 citations , July 2008 in “Acta Biochimica et Biophysica Sinica”

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

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