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GlossaryKeratin 6 (KRT6)

protein in skin, hair, and nails providing structural support

Keratin 6 (K6) is a type of protein found in the epithelial cells of the skin, hair, and nails. It plays a crucial role in the structural integrity and resilience of these tissues. Mutations in the KRT6 gene, which encodes Keratin 6, can lead to disorders such as pachyonychia congenita, characterized by thickened nails and other skin abnormalities.

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research Krt6a-Cre Transgenic Mice Direct LoxP-Mediated Recombination to the Companion Cell Layer of the Hair Follicle and Following Induction by Retinoic Acid to the Interfollicular Epidermis

10 citations , January 2004 in “Journal of Investigative Dermatology”

Krt6a-Cre transgenic mice help study gene effects on hair follicle development and tumor suppression.

research Hair Greying Is Associated With Active Hair Growth

36 citations , September 2011 in “British Journal of Dermatology”

White hair grows thicker and faster than black hair due to higher activity of growth-related genes and proteins.

Dissecting the Role of the Common Neurotrophin Receptor CD271 in the Skin: Generation and Characterization of a Novel Mouse Model with Keratinocyte-Specific Conditional Deletion

research Dissecting the Role of the Common Neurotrophin Receptor CD271 in the Skin: Generation and Characterization of a Novel Mouse Model with Keratinocyte-Specific Conditional Deletion

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Deleting the CD271 gene in mouse skin cells leads to disorganized skin and increased hair growth, suggesting CD271 is important for skin health.

research In Vitro Mesenchymal–Epithelial Interaction Facilitates De Novo Hair Follicle Formation

September 2016 in “Journal of dermatological science”

Adult skin cells can be used to create new hair in a lab.

Comparative Histomorphometric and Transcriptomic Analysis Reveals Potential Genetic Determinants of Pelage Variation Between Hairy and Coarse-Woolly Sheep

research Comparative Histomorphometric and Transcriptomic Analysis Reveals Potential Genetic Determinants of Pelage Variation Between Hairy and Coarse-Woolly Sheep

November 2025 in “BMC Genomics”

Genetic differences in sheep affect wool type, with fat and immune genes influencing hair traits.

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