July 2021 in “PARIPEX INDIAN JOURNAL OF RESEARCH” This study highlighted knuckle hyperpigmentation as an early sign of vitamin B12 deficiency, indicating a potential link to megaloblastic anemia in the vegetarian population in India.
November 2024 in “Rheumatology Advances in Practice” This case report highlights the significance of alopecia totalis and knuckle pad hyperpigmentation as early indicators of azathioprine-induced myelosuppression and pancytopenia.
6 citations
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January 2018 in “Dermato-endocrinology” This study found that acanthosis nigricans in the knuckles correlates with higher insulin and HOMA-IR values, potentially serving as an early, accessible marker for insulin resistance even without excess weight.
9 citations
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October 2014 in “Experimental and Clinical Endocrinology & Diabetes” This study observed that acanthosis nigricans is highly prevalent in Latin American youths, especially at the knuckles, and may indicate early insulin resistance even in those with a normal BMI.
5 citations
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April 2007 in “Expert Review of Dermatology” This abstract is incomplete and does not provide new research findings or conclusions.