385 citations
,
November 1990 in “Journal of Cell Science”
This study successfully grew and maintained human hair follicles in vitro, noting that TGF-β1 negatively affects growth, while EGF replicates hair-removal effects seen in animals.
58 citations
,
December 1992 in “British Journal of Dermatology”
In this study, insulin-like growth factor-1 did not impact hair follicle elongation in rat pelage hair follicles, while transforming growth factor-beta 1 inhibited both elongation and thymidine uptake.
13 citations
,
December 1991 in “Annals of the New York Academy of Sciences”
This study observed that human anagen hair follicles can grow in vitro when maintained serum-free, with possible implications for understanding hair follicle growth mechanisms.
8 citations
,
February 1968 in “Australian Journal of Zoology”
This study describes the structure and composition of the epidermal horny layer in elephant seals, noting that its keratinized cells are attached without a specialized fission zone, differing from the sloughing mechanism in reptiles.
Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.
Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.