This study suggests that an increase in kenogen phases, along with rising vellus hair cycles and fewer normal hair cycles, is associated with the progression of female androgenetic alopecia.
This study describes the kenogen phase, where hair follicles rest after shedding, and finds its duration and frequency are greater in individuals with androgenetic alopecia, potentially contributing to baldness.
28 citations
,
May 2012 in “Veterinary Dermatology”
In this study, dogs with hair cycle disorders, especially those with alopecia X, showed a significant increase in the number of kenogenfollicles, suggesting impaired induction of new hair growth phases.
4 citations
,
April 2016 in “Experimental Dermatology”
This commentary discusses the mechanisms of progression and potential regrowth in androgenetic alopecia, indicating that the initiation of anagen in kenogenfollicles is more critical for hair density improvement than reversing follicle miniaturization.
PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.
PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.
PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.
A 24-year-old person who is worried about their hair loss after 14 months of taking finasteride and 11 months of minoxidil. Replies to the post suggested sticking with their current regimen, that shedding from one part may not be telogen effluvium, and that shedding is normal with these drugs and they should evaluate in two to three months.