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research Missense mutation Y449H of the K10 gene in a patient with severe epidermolytic ichthyosis

3 citations , March 2019 in “European Journal of Dermatology”

A specific gene mutation (Y449H in K10) was found in a patient with severe skin disorder.

research Severe Abnormalities in the Oral Mucosa Induced by Suprabasal Expression of Epidermal Keratin K10 in Transgenic Mice

15 citations , September 2002 in “Journal of Biological Chemistry”

This study observed that transgenic mice expressing keratin K10 under bovine K6beta control developed severe oral abnormalities, suggesting keratin composition changes can affect the physiology of epithelial cells, especially in the oral mucosa.

research Genetic disorders of keratin: are scarring alopecias a sub-set?

14 citations , July 1994 in “Journal of Dermatological Science”

In this study, transgenic mice expressing a mutant K6 gene developed progressive scarring alopecia and keratosis, suggesting they may model a new keratin disorder.

research p63 Regulates Human Keratinocyte Proliferation via MYC-regulated Gene Network and Differentiation Commitment through Cell Adhesion-related Gene Network

82 citations , December 2011 in “Journal of Biological Chemistry”

This study discovered that a network controlled by the gene p63 is crucial for keratinocyte differentiation and is linked to MYC through cell adhesion-related pathways.