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GlossaryJAK inhibitor

blocks enzymes involved in immune response and inflammation

A JAK inhibitor, also known as a Janus kinase inhibitor or JAKi, is a type of medication that blocks the activity of Janus kinase enzymes. These enzymes play a crucial role in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK inhibitors can help manage autoimmune diseases and conditions like alopecia areata, where the immune system mistakenly attacks hair follicles.

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research Small Molecule Inhibitors and Inflammatory Skin Diseases

March 2018 in “Suez Canal University Medical Journal”

New drugs targeting the JAK-STAT pathway show promise for treating inflammatory skin diseases.

research Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata

49 citations , February 2022 in “Drug Design Development and Therapy”

Ritlecitinib shows promise for hair regrowth in alopecia areata patients.

research Janus Kinase Inhibitors for Alopecia Areata: A Narrative Review

2 citations , June 2023 in “Indian journal of dermatology, venereology, and leprology”

Janus kinase inhibitors can regrow hair in alopecia areata but may cause side effects and hair loss may return if treatment stops.

research JAK Inhibitors: New Players in the Field of Immune-Mediated Diseases Beyond Rheumatoid Arthritis

223 citations , September 2018 in “Rheumatology”

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

research Under Development JAK Inhibitors for Dermatologic Diseases

14 citations , January 2020 in “Mediterranean Journal of Rheumatology”

New JAK inhibitor drugs show promise for treating skin diseases but need more research on safety and effectiveness.

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