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GlossaryJAK1/2 inhibitor

medication that blocks enzymes involved in immune signaling

A JAK1/2 inhibitor is a type of medication that blocks the activity of Janus kinase 1 and 2 (JAK1 and JAK2), which are enzymes involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK1/2 inhibitors can help treat conditions like rheumatoid arthritis and certain types of alopecia, where the immune system mistakenly attacks the body's own tissues.

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Small Molecule Inhibitors and Inflammatory Skin Diseases

research Small Molecule Inhibitors and Inflammatory Skin Diseases

March 2018 in “Suez Canal University Medical Journal”

New drugs targeting the JAK-STAT pathway show promise for treating inflammatory skin diseases.

Efficacy of Baricitinib in Patients with Various Degrees of Alopecia Areata Severity: Post-Hoc Analysis from BRAVE AA1 and BRAVE AA2

research Efficacy of Baricitinib in Patients with Various Degrees of Alopecia Areata Severity: Post-Hoc Analysis from BRAVE AA1 and BRAVE AA2

1 citations, September 2023 in “Dermatology and Therapy”

Baricitinib helps improve hair growth in severe alopecia, with better results in less severe cases and higher doses working faster.

Efficacy and Safety of Baricitinib in Patients With Alopecia Areata: Evidence to Date

research Efficacy and Safety of Baricitinib in Patients With Alopecia Areata: Evidence to Date

September 2023 in “Drugs in context”

Baricitinib is a promising treatment for alopecia areata.

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