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GlossaryJAK1/2 inhibitor

medication that blocks enzymes involved in immune signaling

A JAK1/2 inhibitor is a type of medication that blocks the activity of Janus kinase 1 and 2 (JAK1 and JAK2), which are enzymes involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK1/2 inhibitors can help treat conditions like rheumatoid arthritis and certain types of alopecia, where the immune system mistakenly attacks the body's own tissues.

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research Janus Kinase (JAK) Inhibitors for the Treatment of Skin and Hair Disorders: A Review of Literature

40 citations , December 2016 in “Journal of Dermatological Treatment”

JAK inhibitors show promise for treating skin and hair disorders but need more research on long-term safety and effectiveness.

research Under Development JAK Inhibitors for Dermatologic Diseases

14 citations , January 2020 in “Mediterranean Journal of Rheumatology”

New JAK inhibitor drugs show promise for treating skin diseases but need more research on safety and effectiveness.

Ideal JAK Inhibitor for Alopecia Areata: Baricitinib, Tofacitinib, Ritlecitinib, or Ifidancitinib - Revisiting the Immunomechanisms of the JAK Pathway

research Ideal JAK Inhibitor for Alopecia Areata: Baricitinib, Tofacitinib, Ritlecitinib, or Ifidancitinib - Revisiting the Immunomechanisms of the JAK Pathway

January 2023 in “Indian Dermatology Online Journal”

No single ideal JAK inhibitor for alopecia areata has been determined; JAK3 inhibitors may be promising with fewer side effects.

research A Comprehensive Literature Review of JAK Inhibitors in the Treatment of Alopecia Areata

40 citations , June 2021 in “Clinical, cosmetic and investigational dermatology”

JAK inhibitors show promise in effectively treating hair loss from alopecia areata.

research Janus Kinase (JAK) Inhibitors in Treating Alopecia Areata (AA)

September 2014 in “SciBX”

JAK inhibitors may help treat alopecia areata and promote hair regrowth.

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