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    Did you mean JAK-STAT signaling pathway?
    GlossaryJAK-STAT pathway

    transmits signals from cell surface to nucleus for gene expression

    The JAK-STAT pathway, short for Janus kinase-signal transducer and activator of transcription pathway, is a chain of interactions between proteins in a cell that transmits signals from chemical signals outside the cell to the cell nucleus, resulting in DNA transcription and activity changes. This pathway is crucial for regulating immune function, cell growth, and development, and has been implicated in various diseases, including certain types of alopecia and cancers.

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      learn Tofacitinib

      a JAK inhibitor for alopecia areata and other autoimmune conditions

      learn Baricitinib

      JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

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      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 2 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community What else is good. Besides the big 3.

      in Chat  34 upvotes 1 week ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community My country is 100 years behind the US in treating hairloss

      in Treatment  188 upvotes 2 months ago
      In the Czech Republic, doctors are largely unaware of hair loss treatments beyond minoxidil, and finasteride is hard to obtain. Many users suggest buying treatments like finasteride and minoxidil from other countries or online.