research Pulling Force Deforms Hair Follicle Root Sheath Nuclei and Surrounding Dermal Collagen Matrix Differently at Infundibulum, Isthmus, and Suprabulbar Regions
Hair follicles respond differently to pulling forces in various regions.
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5 / 965 resultsresearch Localization of Merkel Cells at Hairless and Hairy Human Skin Sites Using Keratin 18
Merkel cells are more densely found in hairless skin areas like palms and soles.
research Seborrheic Keratosis: A Tumor of the Infundibular and Isthmus of Hair Follicles - Identification of Hair Sheath Keratins and Histopathological Features Suggesting Hair Follicle Origin
Seborrheic keratosis likely originates from the upper regions of hair follicles.
research Matriptase Expression and Zymogen Activation in Human Pilosebaceous Unit
Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.
research Histology and Ultrastructure of Canine Hair Follicle Stem Cells
Canine hair follicle stem cells are located in the isthmus/bulge region of the hair follicle.
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5 / 5 resultscommunity Quote from Pelage (PP-405) Spokesperson...
Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.
community Microneedling depth. Does one length fit all areas of the scalp? Maybe not.
Microneedling depth should be customized based on hair type and scalp area, with many users finding 0.5-0.6mm effective for miniaturized hairs to avoid damage. Users report varying pain levels and results, with some preferring shorter needle lengths and others using longer ones like 1.75mm for scalp health and density improvement.
community Microneedling must reach the stem cells in the upper hair shaft
Microneedling should target depths of 0.5mm to 1.5mm for hair loss, with weekly sessions at 1mm recommended. Combining microneedling with Minoxidil is common for improved results.
community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied
by
nkrata
in Research
830 upvotes
1 year ago Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
community The MPB itch aka DHT itch is very real.
Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.