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research Pulling force deforms hair follicle root sheath nuclei and surrounding dermal collagen matrix differently at infundibulum, isthmus and suprabulbar regions

2 citations , April 2019 in “Experimental Dermatology”

This study observed that applying a pulling force to hair follicles led to significant compression of nuclei in certain cell layers and distinct collagen changes at different follicle depths.

research Seborrheic karatosis, a tumor of the infundibular and isthmus of hair follicles: Identification of hair sheath keratins and histopathological features suggesting hair follicle origin.

2 citations , January 1989 in “The Nishinihon Journal of Dermatology”

This study found that seborrheic keratosis lesions contain high levels of hair sheath keratin, suggesting they may originate from the upper hair follicle.

research Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that hemoglobin α expression in the epidermis is induced by oxidative stress and may function as an antioxidant, contributing to skin barrier function.

research Localization of Merkel cells at hairless and hairy human skin sites using keratin 18

28 citations , September 1995 in “Biochemistry and Cell Biology”

This study localized Merkel cells in human skin, finding them in the basal layer of glabrous skin at palms and soles, and in the interfollicular epidermis and isthmus region of hair follicles.

research Matriptase Expression and Zymogen Activation in Human Pilosebaceous Unit

9 citations , September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

In this study, researchers found that the matriptase-HGF-c-MET pathway may be activated in proliferative cells of human hair follicles and sebaceous glands, suggesting a potential role in hair growth regulation.

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community Microneedling depth. Does one length fit all areas of the scalp? Maybe not.

55 upvotes 4 years ago

Microneedling depth should be customized based on hair type and scalp area, with many users finding 0.5-0.6mm effective for miniaturized hairs to avoid damage. Users report varying pain levels and results, with some preferring shorter needle lengths and others using longer ones like 1.75mm for scalp health and density improvement.

community Microneedling must reach the stem cells in the upper hair shaft

82 upvotes 4 years ago

Microneedling should target depths of 0.5mm to 1.5mm for hair loss, with weekly sessions at 1mm recommended. Combining microneedling with Minoxidil is common for improved results.

community Quote from Pelage (PP-405) Spokesperson...

122 upvotes 10 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

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