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An Innovative Phase 1b Trial Demonstrating Proof-of-Pharmacology for Two Novel IRAK4-Inhibitors Using a Local and Systemic Driven Immune Response

research An Innovative Phase 1b Trial Demonstrating Proof-of-Pharmacology for Two Novel IRAK4-Inhibitors Using a Local and Systemic Driven Immune Response

April 2023 in “Journal of Investigative Dermatology”

Two new IRAK4-inhibitors effectively reduced skin inflammation and immune response markers in healthy volunteers.

research Loss of UBE2N in Keratinocytes Leads to Skin Inflammation and Immune Infiltration Through IRAK1/4-Mediated Processes

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Removing UBE2N from skin cells causes inflammation and immune response, which can be lessened with specific inhibitors.

research Self-Organization Process in Newborn Skin Organoid Formation Inspires Strategy to Restore Hair Regeneration of Adult Cells

92 citations, August 2017 in “Proceedings of the National Academy of Sciences of the United States of America”

Newborn mouse skin cells can grow hair and this process can be recreated in adult cells to potentially help with hair loss.

research Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells

47 citations, March 2019 in “Journal of immunology research”

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

research Fibroblast Heterogeneity and Tertiary Lymphoid Tissues in the Kidney

9 citations, May 2021 in “Immunological Reviews”

Different types of fibroblasts play various roles in kidney repair and aging, and may affect chronic kidney disease outcomes.

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community Got a microscope camera. Here’s the difference between healthy and miniaturized hair

in Progress Pictures 492 upvotes 2 years ago

A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.