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Forecasting Phase 3 Dose-Response for Abrocitinib, an Oral Janus Kinase 1 Selective Inhibitor, Using Investigator’s Global Assessment and Eczema Area and Severity Index

research 170 Forecasting Phase 3 Dose-Response for Abrocitinib, an Oral Janus Kinase 1 Selective Inhibitor, Using Investigator’s Global Assessment and Eczema Area and Severity Index

September 2019 in “Journal of Investigative Dermatology”

In this study, dose-response modeling predicted that once-daily abrocitinib doses of 100 mg and 200 mg may provide a clinically meaningful response in treating moderate-to-severe atopic dermatitis compared to placebo.

research The Alopecia Areata Investigator Global Assessment scale: a measure for evaluating clinically meaningful success in clinical trials

86 citations , January 2020 in “British Journal of Dermatology”

This study developed the Alopecia Areata Investigator Global Assessment (AA-IGA) to measure scalp-hair loss in alopecia areata patients, incorporating perspectives of both patients and clinicians to define treatment success.

research 396 A novel investigator global assessment score for the evaluation of keratosis pilaris

April 2023 in “Journal of Investigative Dermatology”

In this study, the KPAI and KP-IGA scoring systems for assessing keratosis pilaris showed excellent interrater and intrarater reliability, offering standardized measures for clinical and research use.

research Genomic and phenotypic characterization of Investigator Global Assessment (IGA) scale-based endotypes in atopic dermatitis

3 citations , January 2021 in “Journal of The American Academy of Dermatology”

This study observed that atopic dermatitis severity was associated with higher eosinophil counts and FLG variants, suggesting distinct endotypes that may require tailored treatment approaches.

research 44180 Influence of Baseline Disease Severity Defined by Investigator’s Global Assessment on Abrocitinib Efficacy for up to 96 Weeks in Patients With Moderate-to-Severe Atopic Dermatitis: Interim Analysis of JADE EXTEND, a Long-Term Extension Study

September 2023 in “Journal of the American Academy of Dermatology”

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community LLLT seems like it's at least a solid maintenance tool. Can also provide ok regrowth in AA and MPB. - Pubmed

17 upvotes 8 years ago

Low-Level Laser Therapy (LLLT) is seen as a safe and effective method for maintaining hair and promoting regrowth in androgenetic alopecia (AGA) and male pattern baldness (MPB), with devices like the HairMax LaserComb® and iRestore helmet being popular. Some users and professionals are skeptical about its long-term effectiveness and cost.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

14 upvotes 6 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community Summaries of Finasteride Studies

in Research/Science 20 upvotes 1 year ago

Finasteride is effective in promoting hair growth and reversing hair miniaturization in men with androgenetic alopecia, with improvements seen in various studies over different durations. Some users report initial side effects like ball ache, which often resolve as the body adjusts.

community Finally Managed to Download Somebody's Alex pdf so try to share it

in Research/Science 70 upvotes 2 years ago

The conversation discusses a shared PDF about hair loss treatments, which might help those not seeing results with Minoxidil, Finasteride, and RU58841. Some users are skeptical about the content's value and the price charged for it.

community It's amazing how fast Pelage are going through the trials for PP405. From phase 1 to phase 3 in just 3 years is incredible. It has to be the fastest in history

in Chat 51 upvotes 4 months ago

PP405 is progressing rapidly through trials, with mixed opinions on its potential effectiveness. Current treatments like minoxidil and finasteride are still widely discussed, with some users reporting positive results from new formulations.

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