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This study found a strong dose-related increase in the risk of intracranial meningiomas associated with high doses of cyproterone acetate, with some reduction in risk after stopping the treatment.

This case report found that the most likely cause of the patient's seizures and brain tumor was prior radiation exposure, with seizures managed effectively using intravenous lorazepam and subsequent treatment for the brain mass.

This study found that high doses of cyproterone acetate were associated with an increased risk of meningioma, especially with exposure longer than one year.

This report describes a case of meningioma in a transwoman treated long-term with estradiol and cyproterone acetate, suggesting possible concern over female sex steroids and meningioma risk.

This study found that females exposed to high cumulative doses of cyproterone acetate had a 6–20 fold increased risk of developing meningiomas compared to those on lower doses.