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GlossaryMatrix Metalloproteinase-1 (Interstitial Collagenase)

enzyme that breaks down collagen in connective tissues

Matrix Metalloproteinase-1 (MMP-1), also known as interstitial collagenase, is an enzyme that breaks down collagen, a key structural protein in the skin and other connective tissues. This process is crucial for normal tissue remodeling and repair, but excessive MMP-1 activity can contribute to conditions like skin aging and certain diseases by degrading too much collagen.

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research Effect of Conditioned Media Collected from Human Amniotic Fluid-Derived Stem Cells on Skin Regeneration and Photo-Aging

9 citations , February 2014 in “Tissue Engineering and Regenerative Medicine”

Conditioned media from human amniotic fluid-derived stem cells helps skin heal and protects against aging from sun exposure.

research On the Role of Melatonin in Skin Physiology and Pathology

222 citations , January 2005 in “Endocrine journal”

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

research Wound Healing and the Use of Medicinal Plants

170 citations , September 2019 in “Evidence-based Complementary and Alternative Medicine”

Some medicinal plants can help heal wounds and may lead to new treatments.

research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

133 citations , May 2016 in “Cell Host & Microbe”

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

Skin Physiology in Microgravity: A 3-Month Stay Aboard ISS Induces Dermal Atrophy and Affects Cutaneous Muscle and Hair Follicles Cycling in Mice

research Skin Physiology in Microgravity: A 3-Month Stay Aboard ISS Induces Dermal Atrophy and Affects Cutaneous Muscle and Hair Follicles Cycling in Mice

48 citations , May 2015 in “NPJ microgravity”

A 3-month stay in space causes skin thinning, disrupts hair growth, and changes muscle-related genes in mice.

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community Lowering dose of Oral Minoxidil?

in Minoxidil 108 upvotes 9 months ago

The user plans to lower their oral minoxidil dose from 5 mg to 2.5 mg to reduce side effects like puffiness and hypertrichosis, while also using finasteride and accutane. They are considering caffeine serums for puffiness and discussing dietary changes or switching to topical minoxidil to address bloating.

community Questions about alfatradiol logistics

in Treatment 4 upvotes 2 years ago

The user is seeking help with using Ell-Cranell for hair loss treatment. They are unsure about the correct application method and dosage. They also inquire about combining microneedling with topical alfatradiol and question a study that referred to alfatradiol as a hair growth inhibitor in male mice.

community [AMA] 5-Month Progress Report: Dutasteride and Oral Minoxidil Results.

in Minoxidil 74 upvotes 4 years ago

Naepo's 5-month progress report detailing their journey of treating male pattern baldness with dutasteride and oral minoxidil, which has already resulted in an encouraging improvement in hair density. Others have responded with appreciation for the thorough report and asked further questions about Naepo's educational background.

community There must be many of you by now who have stuck with a microneedling program, how'd you make out?

in Technology 14 upvotes 4 months ago

Microneedling with finasteride, minoxidil, DMSO, and black seed oil shows mixed hair regrowth results. There are concerns about DMSO's safety and effectiveness.

community What's "wrong" with oral minoxidil, exactly?

in Minoxidil 173 upvotes 1 year ago

Oral minoxidil can boost hair growth but may cause side effects like heart palpitations and increased body hair. Many prefer topical minoxidil due to fewer side effects.

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