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research Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype

August 2022 in “Nutrients”

This ex vivo study found that hair follicles in female pattern hair loss exhibited nutrient insufficiency and dormant metabolism, but maintained nutrient uptake capability, suggesting potential benefits of nutritional supplementation as an adjunct therapy.

Poor Perifollicular Vascularization Is Associated With Nutrient Insufficiency and a Quiescent Metabolic Phenotype in Intermediate Hair Follicles From Patients With Female Pattern Hair Loss

research 333 Poor perifollicular vascularization is associated with nutrient insufficiency and a quiescent metabolic phenotype in intermediate hair follicles from patients with female pattern hair loss

October 2021 in “Journal of Investigative Dermatology”

In this study, the researchers found that scalp hair follicles affected by female pattern hair loss are poorly vascularized, likely affecting nutrient delivery, but capable of nutrient uptake when supplemented.

research HIGH DEVELOPMENTAL AGE AND POOR HAIR MULTI-ELEMENT PROFILE IN A 3.75-YEAR-OLD GIRL − DIFFERENTIAL RATES IN SHAPING OF BODY ORGAN GROWTH

1 citations , January 2015 in “Trace Elements in Medicine (Moscow)”

This case study reports that different organs, such as hair and stature, may grow at varying rates during different stages of growth.

research An Integrated Analysis of Cashmere Fineness lncRNAs in Cashmere Goats

26 citations , April 2019 in “Genes”

In this study, researchers identified novel long non-coding RNAs related to cashmere fineness in goats, highlighting a potential regulatory network involving lncRNA XLOC_008679 and its target gene KRT35.

Characterization of Metabolic Changes in the Phenotypes of Women with Polycystic Ovary Syndrome in a Large Mediterranean Population from Sicily

research Characterization of metabolic changes in the phenotypes of women with polycystic ovary syndrome in a large Mediterranean population from Sicily

18 citations , July 2019 in “Clinical Endocrinology”

The researchers reported that among Mediterranean Sicilian women with PCOS, Phenotype B exhibited the most severe metabolic abnormalities, notably obesity and altered glucose metabolism, whereas Phenotype D showed no such issues.

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community If PP405 goes systemic this would be quite catastrophic

in Research/Science 4 upvotes 1 year ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community How do you guys use minoxidil twice a day?

in Minoxidil 10 upvotes 5 months ago

The conversation discusses challenges and tips for applying liquid topical minoxidil twice a day, with users sharing their experiences and methods for managing greasy hair. Many users apply minoxidil once at night, and some combine it with finasteride for better results.

community Why do most of you choose finasteride instead of dutasteride?

in Finasteride/Dutasteride 115 upvotes 1 year ago

Finasteride is preferred over dutasteride due to its longer history, more research, and FDA approval, despite dutasteride being more potent. Users report varied side effects, influencing personal treatment choices.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community How is dht not beneficial to you?

in Finasteride/Dutasteride 111 upvotes 7 months ago

DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

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