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GlossaryCD49f (Integrin alpha-6)

protein aiding cell adhesion and migration, crucial for tissue maintenance

CD49f, also known as Integrin alpha-6 or ITGA6, is a protein found on the surface of certain cells that helps them stick to their surroundings. It plays a crucial role in cell adhesion, migration, and signaling, which are important for processes like wound healing and the maintenance of tissues, including hair follicles.

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Demethylation of ITGAV Accelerates Osteogenic Differentiation in a Blast-Induced Heterotopic Ossification In Vitro Cell Culture Model

research Demethylation of ITGAV Accelerates Osteogenic Differentiation in a Blast-Induced Heterotopic Ossification In Vitro Cell Culture Model

11 citations, December 2018 in “Bone”

Removing a methyl group from the ITGAV gene speeds up bone formation in a specific type of bone disease model.

research Mechanical Force Activation of TGF-β Signaling Controls Hair Follicle Regression

April 2023 in “Journal of Investigative Dermatology”

Muscle around hair follicles controls hair loss by releasing a signal that causes cell death.

research The Role of Integrin AlphaVbeta6 in Impaired Wound Healing and Hair Follicle Regeneration

January 2010

Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.

research Targeting Integrin Pathways: Mechanisms and Advances in Therapy

54 citations, January 2023 in “Signal Transduction and Targeted Therapy”

New therapies are being developed that target integrin pathways to treat various diseases.

Expansion of the Spectrum of ITGB6-Related Disorders to Adolescent Alopecia, Dentogingival Abnormalities, and Intellectual Disability

research Expansion of the Spectrum of ITGB6-Related Disorders to Adolescent Alopecia, Dentogingival Abnormalities, and Intellectual Disability

19 citations, December 2015 in “European Journal of Human Genetics”

A rare ITGB6 gene variant causes intellectual disability, hair loss, and dental issues.

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