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research A KRT71 Loss-of-Function Variant Results in Inner Root Sheath Dysplasia and Recessive Congenital Hypotrichosis of Hereford Cattle

2 citations , July 2021 in “Genes”

This study identified a new genetic variant in the KRT71 gene responsible for a breed-specific form of hypotrichosis in Hereford cattle, potentially serving as a model for similar human conditions.

research Abnormal inner root sheath of the hair follicle in the loose anagen hair syndrome: An ultrastructural study

31 citations , December 2010 in “Journal of the American Academy of Dermatology”

This study reports that structural abnormalities in the inner root sheath of hair follicles may cause the hair shaft to be loosely attached in patients with loose anagen hair syndrome.

research Histological and dermatoscopic description of sphynx cat skin

26 citations , August 2014 in “Veterinary Dermatology”

This study found that sphynx cats exhibit hair follicle dysplasia with abnormal hair shaft production, but without a reduction in the number of follicles, similar to murine KRT 71 mutants.

research Study on the expression patterns of inner root sheath-specific genes in Tan sheep hair follicle during different developmental stages

July 2024 in “Gene”

This study analyzed inner root sheath-specific genes in Tan sheep during various growth stages, finding peak expression at birth. The pattern of genes KRT71, KRT72, and TCHH is consistent with wool crimp, potentially influencing wool morphology.

research iRhom2 Mutation Leads to Aberrant Hair Follicle Differentiation in Mice

15 citations , December 2014 in “PLoS ONE”

This study identifies iRhom2 as a crucial regulator of hair follicle differentiation, showing that the iRhom2Uncv mutation leads to dysplasia and reduced TACE maturation, resulting in a hairless phenotype in mice.

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community Why is minoxidil the “regrowth stimulant” and finasteride “the maintenance”, when official studies show more growth on finasteride ?

in Research/Science 46 upvotes 6 months ago

Finasteride is more effective for long-term hair maintenance by addressing the root cause of hair loss, while minoxidil acts as a growth stimulant with faster visible results. Combining both treatments is optimal, with oral minoxidil often showing better results for some individuals.

community UV radiation is harmfull for hair

3 upvotes 4 years ago

community Acne as a result of Finasteride

1 upvotes 4 years ago

community My understanding of how androgenetic alopecia works (plus FIN and DUT)

18 upvotes 4 years ago

Androgenetic alopecia is affected by scalp DHT levels, not sensitivity, with treatments like finasteride and dutasteride aiming to optimize these levels. Personalized DHT management is crucial for effective hair growth.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

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