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5 / 13 resultslearn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
learn Epidermal Growth Factor
learn Baricitinib
JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases
learn Tofacitinib
a JAK inhibitor for alopecia areata and other autoimmune conditions
Research
5 / 1000+ results
research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase
New compounds were made that block an enzyme linked to breast cancer better than existing treatments.
research Determination of the Potency of a Novel Saw Palmetto Supercritical CO2 Extract for 5α-Reductase Isoform II Inhibition Using a Cell-Free In Vitro Test System
The new saw palmetto extract effectively inhibits an enzyme linked to prostate enlargement and may be as good as standard treatments.
research Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors
New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.
research Potency of a Novel Saw Palmetto Ethanol Extract, SPET-085, for Inhibition of 5α-Reductase II
SPET-085 effectively inhibits an enzyme linked to prostate issues, similar to finasteride.
research Determination of the Potency of a Novel Saw Palmetto Supercritical CO2 Extract (SPSE) for 5-Alpha-Reductase Isoform II Inhibition Using a Cell-Free In Vitro Test System
The saw palmetto extract effectively inhibits an enzyme linked to prostate issues, showing promise for prostate health.
Community Join
5 / 1000+ resultscommunity Rosemary oil's potency as a dht blocker
Rosemary extract showed high inhibitory activity against DHT, similar to finasteride and dutasteride, but the conversation includes skepticism about its effectiveness in humans since the study was done on mice and rosemary oil is often considered ineffective based on personal experiences. Some suggest trying rosemary oil alongside other treatments, while others emphasize the difference between the extract used in the study and the oil.
community FCE 28260: A Forgotten 5α-Reductase Inhibitor
by
nkrata
in Research
330 upvotes
1 year ago FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
community Does anyone know what % of DHT does topical azelaic acid blocks?
The conversation is about the effectiveness of topical azelaic acid in blocking DHT for hair loss treatment. Specific treatments discussed include Minoxidil, finasteride, and RU58841.
community Serenoa Repens (saw palmetto) + plus biotin
A user is using minoxidil for hair loss and considering adding finasteride but their dermatologist advised waiting to see if minoxidil works alone. They are thinking about taking saw palmetto (serenoa repens) and biotin as alternatives and are asking for others' experiences and potential side effects.
community Doctors won't let me try bicalutamide or fin
Hair loss treatments discussed include 200mg Spiro, bicalutamide, and finasteride. Endocrinologist advises against bicalutamide and finasteride due to potency and risks.