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Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery

research Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery

11 citations , May 2010 in “Journal of Medicinal Chemistry”

This study introduced a novel nonsteroidal androgen receptor antagonist that effectively controls sebum production in the golden Syrian hamster ear model through targeted follicular delivery.

research Steroid inhibitors of androgen-potentiated actions on skin

4 citations , July 1983 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry”

In this study, hirsute women treated with cyproterone acetate and ethinyloestradiol experienced significant reductions in sebum secretion and hair growth after several months.

Dermal Fibroblasts Enhance Growth Factors Production by Androgens and Modulate Keratinocyte Proliferation and Differentiation

research 854 Dermal fibroblasts enhance growth factors production by androgens, and modulate keratinocyte proliferation and differentiation

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that testosterone and dihydrotestosterone can induce growth factors from dermal fibroblasts, promoting keratinocyte proliferation and differentiation, which may contribute to sex hormone-related acne development.

Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men with Suppressed Testosterone Production: A Randomized Controlled Trial

research Re: Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men with Suppressed Testosterone Production: A Randomized Controlled Trial

July 2012 in “The Journal of Urology”

This abstract reviews testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production and reports no new research findings.

research Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases

11 citations , February 2016 in “Current Medicinal Chemistry”

This review discusses various targets for treating prostate cancer and benign prostatic hyperplasia and reports on recent studies of new compounds and 5α-reductase inhibitors, but provides no new experimental results.

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community Dutasteride: More Than a DHT Reducer – A Potential Androgen Receptor Inhibitor?

in Finasteride/Dutasteride 31 upvotes 1 year ago

Dutasteride may inhibit androgen receptors in addition to reducing DHT, potentially explaining its effectiveness over finasteride for hair loss. Concerns about its impact on muscle growth are debated, with some suggesting no significant effects.

community How to deal with overproduction of sebum?

10 upvotes 1 month ago

The user is experiencing diffuse thinning and excessive sebum production, considering Accutane as a potential solution after trying dutasteride and oral minoxidil without success. Other users suggest treatments like Nizoral shampoo, finasteride, beclomethasone dipropionate lotion, and topical androgen receptor inhibitors.

community Minoxidil is a 5ar inhibitor according to research

150 upvotes 11 months ago

Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

community Consenus on Kx-826/pyrilutamide vs ru58841

11 upvotes 2 weeks ago

KX-826 is considered effective for hair maintenance, with better safety research than RU58841, but lacks positive anecdotes. RU58841 is seen as potentially stronger, but concerns exist about systemic effects; combining anti-androgens with 5AR inhibitors is suggested for better results.

community A better treatment would be a localized 5ar inhibitor that breaks down when it enters blood or leaves hair follicle

1 upvotes 1 year ago

The conversation discusses the need for a localized 5-alpha reductase inhibitor that only affects the scalp without systemic side effects, similar to pyrilutamide's approach. Current treatments like topical liposomal finasteride and dutasteride are mentioned, but concerns about their systemic effects and lack of research are highlighted.

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Learn

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learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Overview

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Epidermal Growth Factor

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Bicalutamide

Can bicalutamide stop DHT from shrinking your hair follicles? Bicalutamide blocks androgens at the receptor rather than lowering DHT, and some dermatologists prescribe it off-label for women with pattern hair loss. The published evidence is retrospective case series and one small pilot study, with no randomized trial; it is a prescription drug that requires liver monitoring and is contraindicated in pregnancy.

learn Fluridil

How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.

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