111 citations
,
August 2002 in “Journal of Medicinal Chemistry”
This study reports that 2-(1-Adamantyl)-4H-thiochromen-4-on-6-O-sulfamate is the most potent steroid sulfatase inhibitor identified so far, exhibiting 170-fold higher activity than the lead compound estrone sulfamate.
This study found that treatment with finasteride in fetal sheep reduced the protective neurosteroid allopregnanolone, leading to increased cell death in the hippocampus following induced fetal asphyxia.
91 citations
,
December 2000 in “The journal of cell biology/The Journal of cell biology”
This study reports that expressed mouse type Ia and type IIa trichocyte keratins were successfully assembled into intermediate filaments in vitro, while also suggesting that disulfide bond cross linking enhances their stability.
The conversation discusses the use of oral versus topical minoxidil for hairline recession, with concerns about collagen synthesis inhibition. Oral minoxidil may affect collagen production more broadly, while topical minoxidil's effects are localized but may cause skin issues.
The post discusses using a topical tincture containing zinc, azelaic acid, and other ingredients to inhibit 5 alpha-reductase activity for treating hair loss. The user plans to try this natural alternative before using finasteride or RU58841.
Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.
The conversation discusses using P5P (Vitamin B6) supplements to reduce elevated Prolactin levels and concerns about its potential effect on increasing DHT levels. The user is not currently using finasteride or any anti-androgens.
Turmeric may slightly inhibit DHT, but it likely doesn't significantly impact hair loss. Creatine might increase DHT levels, but its effect on hair loss is debated and not conclusively proven.