research 1117 PX-12 inhibits NLRP3 inflammasome activation to treat psoriasis
This study found that PX-12 inhibited the NLRP3 inflammasome and reduced psoriasis-like symptoms in a mouse model, suggesting its potential as a treatment for psoriasis.
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5 / 725 results research Baricitinib Attenuates IFN-γ and Polyinosinic:polycytidylic Acid‒Induced Mitochondrial Damage and Inflammasome Activation in Human Keratinocytes
Baricitinib reduces inflammation and mitochondrial damage in skin cells.
research Pyroptosis in Alopecia Areata: Synthesizing Emerging Hypotheses and Charting a Path to New Therapies
In this review, researchers reported that pyroptosis, a type of inflammatory cell death linked to inflammasome activity, is a key factor in the pathogenesis of alopecia areata and may present new therapeutic opportunities, though most treatments are still in early research stages.
research 642 Uncovering the role of UV exposure history and genetics in determining skin sun damage
This study found that facial sun damage scores from UV photography correlate with skin cancer and melanoma risk factors, suggesting this technology may help identify individuals at higher risk.
research Novel TMEM173 Mutation and the Role of Disease Modifying Alleles
This study identified a novel G207E STING mutation associated with severe inflammatory symptoms and suggested that common polymorphisms in TMEM173 and IFIH1 may modify the phenotype in affected individuals.
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