This article explores the hormonal and genetic factors influencing androgenetic alopecia and identifies potential targets for treatment but reports no new clinical findings.
This literature review found that androgenetic alopecia has a complex multifactorial etiology and effective management should be tailored to individual severity and gender to improve patients' quality of life.
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May 1986 in “Clinics in endocrinology and metabolism”
This review discusses the influence of androgens on hair and sebaceous growth, emphasizing that response may depend more on peripheral sensitivity than on hormone levels; it reports no new empirical results.
This paper proposes a theory explaining how the normal anabolic effects of androgens lead to structural changes and hair follicle miniaturization, contributing to androgenic alopecia.
This study found that early life stress significantly affects hedonic sensitivity to high-palatable food by altering gonadal hormones in prenatally-stressed male and female rats, with sex-dependent changes in reward-related behaviors and neurochemistry.
Hair loss can persist despite using treatments like finasteride, dutasteride, and minoxidil due to factors like genetic sensitivity, incomplete DHT blockage, and other hormonal influences. Individual responses vary, and some may require a combination of treatments to stabilize hair loss.
Finasteride and dutasteride may cause erectile dysfunction due to reduced DHT, affecting nitric oxide and sexual function. Some suggest using aromatase inhibitors to address side effects, while others believe individualsensitivity to DHT reduction varies.
Diffuse thinners often experience more hair regrowth with DHT blockers like finasteride, possibly due to less DHTsensitivity and the presence of miniaturized, not completely bald, follicles. However, regrowth varies widely among individuals, influenced by factors like genetics, the stage of hair loss, and treatment methods such as minoxidil, microneedling, and dermarolling.
Dutasteride and finasteride are effective for many in reducing hair loss by lowering DHT levels, though results vary based on individualsensitivity and genetics. Higher doses of dutasteride may not significantly increase hair growth due to diminishing returns, and topical finasteride is suggested as an alternative for some.
Hair loss is primarily caused by genetic sensitivity to DHT, not lifestyle factors like diet or exercise. Treatments like Minoxidil and Finasteride can help, but it's important to consult a dermatologist to determine the best approach for individual cases.
Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.