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GlossaryImmunohistochemical Methods

use antibodies to detect specific proteins in tissue samples

Immunohistochemical Methods, often abbreviated as IHC Methods, are laboratory techniques used to visualize specific proteins or antigens in tissue samples. By applying antibodies that bind to these targets and then using a color change or fluorescent marker, scientists and medical professionals can identify the presence and distribution of particular molecules, aiding in disease diagnosis and research.

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research Immunohistochemical Localization of TGF-β in Alopecia Areata

July 1997 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

TGF-β is found in hair follicles and may cause hair loss in alopecia areata.

research A Practical Guide for the Study of Human and Murine Sebaceous Glands In Situ

56 citations , September 2013 in “Experimental Dermatology”

The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.

research The Microanatomy of the Distal Arrector Pili: Possible Role for α1β1 and α5β1 Integrins in Mediating Cell-Cell Adhesion and Anchorage to the Extracellular Matrix

15 citations , February 2000 in “Journal of Cutaneous Pathology”

The arrector pili muscle attaches to the extracellular matrix using α5β1 integrin and connects muscle cells using α1β1 integrin.

research Characteristic Intraepidermal Nerve Fiber Endings of the Intervibrissal Fur in the Mystacial Pad of the Rat: Morphological Details Revealed by Intravital Methylene Blue Staining and the Zinc Iodide-Osmium Tetroxide Technique

5 citations , July 1999 in “Journal of Anatomy”

Methylene blue staining effectively highlights detailed nerve structures in rat fur.

research Comment on Scalp Neuropathy in Androgenetic Alopecia

1 citations , April 2022 in “Journal of The American Academy of Dermatology”

Hair loss in men (androgenetic alopecia) is significantly linked to decreased scalp sensitivity, but not temperature sensitivity. More research is needed to confirm this. Comparing this hair loss to leprosy is unsupported and stigmatizing.

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community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 413 upvotes 8 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 676 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Another clueless guy fearmongering and spreading misinformation

in Chat 251 upvotes 1 year ago

The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.