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research Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing

176 citations , August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.

research Extensive alopecia areata is reversed by IL-12/IL-23p40 cytokine antagonism

68 citations , November 2015 in “The Journal of Allergy and Clinical Immunology”

In this study, three patients with extensive alopecia areata showed varying degrees of hair regrowth after 20 weeks of treatment with ustekinumab, a cytokine-targeting therapy.

research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

144 citations , November 2020 in “Frontiers in immunology”

This study summarizes how the IL-23/IL-17 axis contributes to inflammatory skin diseases like psoriasis and highlights that biologics targeting this pathway, including monoclonal antibodies against IL-23 and IL-17, have shown efficacy in clinical trials for these conditions.

research IL-12/IL-23 neutralization is ineffective for alopecia areata in mice and humans

20 citations , December 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

In this study, ustekinumab did not promote hair regrowth in human patients with alopecia areata or prevent disease development in an AA mouse model, suggesting limited efficacy for this treatment.

research IL-17 axis is a significant driver of skin inflammation in Card14 mutant pityriasis rubra pilaris model mice

February 2023 in “Research Square (Research Square)”

This study reports that a new mouse model with a CARD14 mutation successfully mimics key human PRP symptoms, and anti-IL-17A antibody significantly reduces these symptoms.

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Learn

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learn Hair Transplant

How many grafts do I need for a hair transplant? You typically need 1,000 to 7,000 grafts depending on hair loss extent and goals.

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Community Join

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community Started minoxidil 2 month ago just noticed an important increase in hair shedding is it normal ?

59 upvotes 1 month ago

Minoxidil can cause increased hair shedding initially, which is normal. Finasteride is available in France, but may require a special doctor's note and check-up.

community My dermatologist won’t prescribe me Fin

79 upvotes 1 year ago

A 23-year-old Italian man in Switzerland is experiencing hair loss and cannot get a prescription for Finasteride, only Minoxidil. He seeks advice on obtaining Finasteride through online pharmacies or by consulting different doctors.

community 4 months!! We making progress!!

506 upvotes 1 year ago

A user shared their successful hair regrowth journey using 0.5 mg Dutasteride, 2.5 mg oral Minoxidil, and Biotin gummies, after switching from Finasteride due to insomnia. They highlighted the importance of brushing the scalp for blood flow and reported significant progress in four months without side effects.

community Pls advice needed. 17-20 yo. Not seeing the progress I hoped for on finasteride + minoxidil. Any advice?

in Progress Pictures 22 upvotes 6 months ago

A user is experiencing hair loss despite using topical minoxidil, oral finasteride, and 2% ketoconazole shampoo, and is seeking advice on further treatments. Suggestions include switching to dutasteride, trying oral minoxidil, addressing scalp inflammation, and considering dietary changes and supplements.

community Failed HT or expected result? 4505 grafts, Eugenix, New Delhi.

in Transplants 36 upvotes 1 year ago

The hair transplant at Eugenix in New Delhi resulted in poor density and texture, with only about 2,500 grafts surviving out of 4,500. The user is considering holding the clinic accountable and exploring options like shaving, using hair fibers, or seeking another transplant.

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Experts

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Clinics

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