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research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

144 citations , November 2020 in “Frontiers in immunology”

This study summarizes how the IL-23/IL-17 axis contributes to inflammatory skin diseases like psoriasis and highlights that biologics targeting this pathway, including monoclonal antibodies against IL-23 and IL-17, have shown efficacy in clinical trials for these conditions.

research Advances in the Molecular Pathogenesis and Targeted Therapy of Psoriasis

May 2025 in “Galen Medical Journal”

This research highlights advancements in understanding and treating psoriasis, finding that targeted therapies like IL-17 and IL-23 inhibitors show promise, but challenges such as adverse events, treatment resistance, and the need for personalized approaches remain.

research Autoimmunity and autoimmune co-morbidities in psoriasis

49 citations , January 2018 in “Immunology”

This review discusses the relationship between psoriasis and autoimmunity, focusing on autoimmune co-morbidities, but reports no new research findings.

research Alopecia Diffusa while Using Interleukin-17 Inhibitors against Psoriasis Vulgaris

20 citations , March 2019 in “Case Reports in Dermatology”

This report describes two cases where patients developed alopecia while undergoing treatment for psoriasis with IL-17 inhibitors, suggesting an unexpected paradoxical reaction.

research IL-17 axis is a significant driver of skin inflammation in Card14 mutant pityriasis rubra pilaris model mice

February 2023 in “Research Square (Research Square)”

This study reports that a new mouse model with a CARD14 mutation successfully mimics key human PRP symptoms, and anti-IL-17A antibody significantly reduces these symptoms.

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Community Join

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community Hair Loss “Cure” for Inflammation: Topical Roflumilast

in Research/Science 32 upvotes 8 months ago

Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

community Pls advice needed. 17-20 yo. Not seeing the progress I hoped for on finasteride + minoxidil. Any advice?

in Progress Pictures 22 upvotes 6 months ago

A user is experiencing hair loss despite using topical minoxidil, oral finasteride, and 2% ketoconazole shampoo, and is seeking advice on further treatments. Suggestions include switching to dutasteride, trying oral minoxidil, addressing scalp inflammation, and considering dietary changes and supplements.

community 4 months!! We making progress!!

506 upvotes 1 year ago

A user shared their successful hair regrowth journey using 0.5 mg Dutasteride, 2.5 mg oral Minoxidil, and Biotin gummies, after switching from Finasteride due to insomnia. They highlighted the importance of brushing the scalp for blood flow and reported significant progress in four months without side effects.

community 8 years of hair loss, turning 30 next month

in Progress Pictures 151 upvotes 1 year ago

The user has been dealing with hair loss for 10 years, worsened by psoriasis, and uses minoxidil and finasteride. They seek advice on managing psoriasis and hair loss, with suggestions to see a dermatologist, try different shampoos, and be patient.

community Why not just take the drugs before hair loss?

in Chat 123 upvotes 6 months ago

Finasteride and dutasteride are discussed as preventative treatments for hair loss, with some advocating for early use and others concerned about side effects, especially before full maturity. Many regret not starting these treatments earlier due to their effectiveness in preventing or slowing hair loss.

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Learn

2 / 801 results

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Hair Transplant

How many grafts do I need for a hair transplant? You typically need 1,000 to 7,000 grafts depending on hair loss extent and goals.

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