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research Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency

15 citations , January 2010 in “Experimental Dermatology”

This study found that maternal iron-restricted diets increased alopecia incidence in IL-10-deficient mouse pups with mast cells, implicating mast cells as potential effectors in this process.

research Interleukin-10-deficient Mice Are Less Susceptible to the Induction of Alopecia Areata

31 citations , October 2002 in “Journal of Investigative Dermatology”

IL-10 may worsen alopecia areata instead of helping it.

research The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice

59 citations , July 2015 in “Journal of Immunology”

This study found that disrupting inflammasome signaling by eliminating caspase-1 and -11 in mice reduced skin inflammation and delayed the onset of disease, highlighting their role in skin disease pathogenesis.

Pregnancy in Postpartum Estrus Induces Inflammatory Milk Production and Catagen-Specific Pup Skin Inflammation in Interleukin-10 Deficient Mice

research Pregnancy in postpartum estrus induces inflammatory milk production and catagen specific pup skin inflammation in interleukin-10 deficient mice

4 citations , July 2013 in “Journal of Dermatological Science”

This study found that interleukin-10 deficiency in B6 mice led to inflammatory milk production due to maternal stress, causing alopecia and hepatocyte steatosis in pups.

research Egr-1 is main key regulator in IL-17F-induced psoriasin expression in human keratinocytes

April 2012

This study found that patients with psoriasis had a significantly higher prevalence of autoimmune diseases and other comorbidities compared to individuals without psoriasis.

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Community Join

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community Why I believe PFS is not a "real" condition (and what I believe it is instead)

14 upvotes 3 years ago

The post argues that Post-Finasteride Syndrome (PFS) is likely not real and suggests symptoms may be due to mental health issues or the nocebo effect. The conversation includes personal experiences with finasteride, highlighting both positive and negative effects, and emphasizes consulting doctors and using reliable sources for medication.

community 8 years of hair loss, turning 30 next month

in Progress Pictures 151 upvotes 1 year ago

The user has been dealing with hair loss for 10 years, worsened by psoriasis, and uses minoxidil and finasteride. They seek advice on managing psoriasis and hair loss, with suggestions to see a dermatologist, try different shampoos, and be patient.

community Part 2 of previous post including pictures

21 upvotes 2 weeks ago

The user has been experiencing hair loss despite using finasteride and dutasteride, with recent photos showing significant thinning. They are considering increasing their dutasteride dosage and possibly trying microneedling, while also addressing concerns about diet and nutrient deficiencies.

community do any supplements actually work?

6 upvotes 2 years ago

A user asked if collagen or hair growth supplements made their hair thicker. Another user suggested that Vitamin D might help if deficient.

community how do you produce more thick white cum while on fin?

in Finasteride/Dutasteride 139 upvotes 5 months ago

Finasteride can reduce semen volume due to prostate shrinkage but doesn't affect fertility. To increase semen volume, consider zinc, lecithin, and reducing finasteride dosage.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Hair Transplant

How long do hair transplants last? Hair transplants are typically permanent, but surrounding hair may thin over time.
What is the success rate of hair transplants? Hair transplants generally have a high success rate, but results can vary.
Is a hair transplant painful? A hair transplant is generally comfortable due to local anesthesia, with mild post-procedure soreness possible.
All 5 questions on Hair Transplant →

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Clinics

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Experts

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