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This study found that the methylation level of the IGFBP4 promoter is negatively correlated with mRNA expression and may serve as an epigenetic marker for wool fineness in Super Merino sheep.

This study found that a 4:1 combination of Rhynchosia nulubilis and Polygonum multiflorum extracts significantly promoted the proliferation of human dermal papilla cells and alleviated testosterone-induced cytotoxicity, suggesting potential for treating hair loss and related disorders through a synergistic approach.

This study found that cortisol increases mac25/IGFBP-rP1 expression in osteoblast-enriched cells from fetal rat calvariae, indicating transcriptional regulation which may influence IGF and insulin effects in bone.

This study found that dermal papilla cells from balding scalp follicles secrete significantly less insulin-like growth factor-1 and its binding proteins, suggesting a mechanism contributing to male pattern baldness.

Secreted inhibitors of Wnt and IGF signaling control hair and tooth development, creating species-specific patterns.