219 citations
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January 2006 in “Drug Metabolism Reviews” DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.
26 citations
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June 2000 in “Journal of The American Academy of Dermatology” Men with balding at age 45 had higher IGF-1 and lower IGFBP-3, suggesting these factors might be important in male pattern baldness.
3 citations
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June 2000 in “Journal of The American Academy of Dermatology” Men with balding at age 45 had higher IGF-1 and lower IGFBP-3 levels, suggesting these factors might influence male pattern baldness.
April 2026 in “European Journal of Medical and Health Research” This study investigated the relationship between serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) with female pattern hair loss (FPHL) in 84 women, including 64 patients with FPHL and 20 controls. Results showed that women with FPHL had significantly lower IGF-1 levels compared to controls, while IGFBP-3 levels were not significantly different. Elevated ferritin levels were observed in FPHL cases, with a weak positive correlation to hair loss severity, whereas IGF-1 and IGFBP-3 had weak inverse correlations with severity that were not statistically significant. The study suggests a potential role of reduced IGF-1 in FPHL, but further research is needed to clarify the IGF axis's role in hair follicle biology.
25 citations
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December 2008 in “The Journal of Urology” Short-term finasteride treatment may lower some cell death factors in prostate cancer cells.