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research Qiviut cortisol reflects hypothalamic–pituitary–adrenal axis activity in muskoxen (Ovibos moschatus)

7 citations , May 2021 in “General and comparative endocrinology”

This study concluded that qiviut cortisol can be used as a measure of HPA axis activity in muskoxen, with hair growth phase and body region affecting cortisol levels.

Involvement of Neurosteroids in the Control of Hypothalamic-Pituitary-Adrenal Axis Activity in Pregnant Sheep Under Basal and Stressful Conditions

research Involvement of neurosteroids in the control of hypothalamic-pituitary-adrenal axis activity in pregnant sheep under basal and stressful conditions

4 citations , August 2021 in “Theriogenology”

This study found that blocking neurosteroid synthesis in pregnant sheep increased HPA axis activity, particularly under stress, suggesting neurosteroids help modulate stress response.

research Faculty Opinions recommendation of Hair cortisol levels as a retrospective marker of hypothalamic-pituitary axis activity throughout pregnancy: comparison to salivary cortisol.

April 2011 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Hair cortisol is a reliable long-term stress marker during pregnancy.

research Hair cortisol: an indicator of HPA activity in relation to environmental perception in New Zealand White rabbit.

January 2012 in “CINECA IRIS Institutial Research Information System (University of Genoa)”

This study observed fluctuations in hair cortisol levels in rabbits, indicating their HPA axis activity responded similarly to surgical and environmental stressors, suggesting potential anthropomorphic evaluations of stress.

research Hair loss and hypothalamic-pituitary-adrenocortical axis activity in captive rhesus macaques (Macaca mulatta).

28 citations , May 2014 in “PubMed”

This study found that increased hair cortisol levels, indicating stress, were associated with greater hair loss in captive rhesus macaques, although the causality of this relationship remains unclear.

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community EMA is re-examining Winlevi (clascoterone at lower concentration)

8 upvotes 1 year ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community Mechanism of action of alfatradiol (17 alpha estradiol)

5 upvotes 2 years ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community CB-03-01 / Breezula Personal Results

17 upvotes 7 months ago

The user shared their experience with CB-03-01 (Breezula/Clascoterone) for hair loss, noting reduced shedding and improved hair appearance but experiencing significant sleep disturbances and low energy due to HPA axis suppression. They decided to stop using it due to these side effects and are waiting for GT20029 as an alternative.

community Does the watery ejaculate issue ever resolve?

in Finasteride/Dutasteride 100 upvotes 7 months ago

Dutasteride and finasteride can cause watery ejaculate, which may persist for some users. Zinc supplements or switching to topical treatments are suggested to alleviate this side effect.

community This could be it!!! New treatment increase hair 500%

340 upvotes 9 months ago

Clascoterone (Breezula) shows a potential 500% increase in hair growth, possibly outperforming minoxidil and finasteride. It is in advanced trials, with hopes for FDA approval, but cost and side effects are concerns.

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