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research Sex Differences in the Hypothalamic–Pituitary–Adrenal Axis’ Response to Stress: An Important Role for Gonadal Hormones

197 citations , January 2019 in “Neuropsychopharmacology”

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

research Expression of Hypothalamic-Pituitary-Thyroid Axis Related Genes in Human Skin

155 citations , December 2002 in “Journal of Investigative Dermatology”

Thyroid-related genes are active in skin cells and may affect autoimmune conditions.

research Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles

95 citations , August 2013 in “Journal of Investigative Dermatology”

HPT axis hormones boost mitochondrial function and growth in hair follicles, potentially aiding hair health.

research Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male

70 citations , March 2016 in “Urologic Clinics of North America”

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

research Hair Loss And Hypothalamic-Pituitary-Adrenocortical Axis Activity In Captive Rhesus Macaques (Macaca Mulatta)

28 citations , May 2014 in “PubMed”

Higher stress levels may be linked to hair loss in rhesus macaques.

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Community Join

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community EMA is re-examining Winlevi (clascoterone at lower concentration)

in Treatment 9 upvotes 5 months ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 1 year ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

in Treatment 3 upvotes 2 years ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

community Pyrilutamide: Increased libido. Anyone else experienced something similar with either RU or Pyri?

in Product 18 upvotes 3 years ago

An increase in libido associated with the use of Pyri, and a discussion about how it may be working comparably to other hair loss treatments such as RU58841, Finasteride and Minoxidil.

community Anyone remember Breezula, the promising hairloss drug that was perpetually 3 years away? Well, it's available right now as an acme treatment. Can we just directly apply to the scalp?

in Treatment 40 upvotes 4 years ago

The conversation discusses the availability of Breezula, a drug for hair loss, now being sold as an acne treatment, and whether it can be applied to the scalp. Users express skepticism about new hair loss treatments and suggest waiting for FDA approval.

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